The molecular imprinting technique was used to regulate the extent of protein adsorption on a surface. Specifically, molecularly imprinted surfaces with poly(ethylene glycol), PEG-grafted chains have shown selective adsorption toward the parental protein molecules in the static adsorption experiment. No such effect was noticed for the dynamic experiment. This may arise from the difference in experimental designs. Apparently, from the results obtained, it may be concluded that the selectivity of the molecularly imprinted surface is present when there is enough time for the molecule to rearrange to attain the same geometrical position as the molecule used for the imprint preparation. Rapid interactions that develop between the molecule and the molecularly imprinted surface in a dynamic experiment do not result in significant specificity.